Molecular sensors of blood flow in endothelial cells
Mechanical stress from blood flow has a significant effect on endothelial physiology, with a
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …
β1 integrins as therapeutic targets to disrupt hallmarks of cancer
AF Blandin, G Renner, M Lehmann… - Frontiers in …, 2015 - frontiersin.org
Integrins belong to a large family of αβ heterodimeric transmembrane proteins first
recognized as adhesion molecules that bind to dedicated elements of the extracellular …
recognized as adhesion molecules that bind to dedicated elements of the extracellular …
[HTML][HTML] mTORC1 activity is supported by spatial association with focal adhesions
The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogenic and stress
signals to control growth and metabolism. Activation of mTORC1 by amino acids and growth …
signals to control growth and metabolism. Activation of mTORC1 by amino acids and growth …
Research advances on structure and biological functions of integrins
L Pan, Y Zhao, Z Yuan, G Qin - Springerplus, 2016 - Springer
Integrins are an important family of adhesion molecules that were first discovered two
decades ago. Integrins are transmembrane heterodimeric glycoprotein receptors consisting …
decades ago. Integrins are transmembrane heterodimeric glycoprotein receptors consisting …
ST6Gal-I–mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion
Heterogeneity within the glycocalyx influences cell adhesion mechanics and signaling.
However, the role of specific glycosylation subtypes in influencing cell mechanics via …
However, the role of specific glycosylation subtypes in influencing cell mechanics via …
EGFR and HER2 activate rigidity sensing only on rigid matrices
Epidermal growth factor receptor (EGFR) interacts with integrins during cell spreading and
motility, but little is known about the role of EGFR in these mechanosensing processes. Here …
motility, but little is known about the role of EGFR in these mechanosensing processes. Here …
Tenascin‐C in brain injuries and edema after subarachnoid hemorrhage: findings from basic and clinical studies
H Suzuki, M Fujimoto, F Kawakita, L Liu… - Journal of …, 2020 - Wiley Online Library
Subarachnoid hemorrhage (SAH) by a rupture of cerebral aneurysms remains the most
devastating cerebrovascular disease. Early brain injury (EBI) is increasingly recognized to …
devastating cerebrovascular disease. Early brain injury (EBI) is increasingly recognized to …
EGFR activation attenuates the mechanical threshold for integrin tension and focal adhesion formation
Mechanical forces, growth factors and the extracellular matrix all play crucial roles in cell
adhesion. To understand how epidermal growth factor receptor (EGFR) impacts the …
adhesion. To understand how epidermal growth factor receptor (EGFR) impacts the …
MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling
MUC5AC is a secretory mucin aberrantly expressed in various cancers. In lung cancer,
MUC5AC is overexpressed in both primary and metastatic lesions; however, its functional …
MUC5AC is overexpressed in both primary and metastatic lesions; however, its functional …
Annexin A6—A multifunctional scaffold in cell motility
T Grewal, M Hoque, JRW Conway… - Cell adhesion & …, 2017 - Taylor & Francis
ABSTRACT Annexin A6 (AnxA6) belongs to a highly conserved protein family characterized
by their calcium (Ca2+)-dependent binding to phospholipids. Over the years …
by their calcium (Ca2+)-dependent binding to phospholipids. Over the years …