TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Phosphoinositide regulation of TRP channels: A functional overview in the structural era
T Rohacs - Annual Review of Physiology, 2024 - annualreviews.org
Transient receptor potential (TRP) ion channels have diverse activation mechanisms
including physical stimuli, such as high or low temperatures, and a variety of intracellular …
including physical stimuli, such as high or low temperatures, and a variety of intracellular …
Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A
BH Lee, JJ De Jesús Pérez, V Moiseenkova-Bell… - Nature …, 2023 - nature.com
Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays
important cellular regulatory roles, including activation and inhibition of ion channels. The …
important cellular regulatory roles, including activation and inhibition of ion channels. The …
Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel
Cyclic nucleotide-gated (CNG) channels transduce chemical signals into electrical signals in
sensory receptors and neurons. They are activated by cGMP or cAMP, which bind to the …
sensory receptors and neurons. They are activated by cGMP or cAMP, which bind to the …
Structural basis of TRPV1 inhibition by SAF312 and cholesterol
Abstract Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain
sensation and is thus an attractive pharmacological drug target. SAF312 is a potent …
sensation and is thus an attractive pharmacological drug target. SAF312 is a potent …
Molecular details of ruthenium red pore block in TRPV channels
RA Pumroy, JJ De Jesús-Pérez, AD Protopopova… - EMBO …, 2024 - embopress.org
Transient receptor potential vanilloid (TRPV) channels play a critical role in calcium
homeostasis, pain sensation, immunological response, and cancer progression. TRPV …
homeostasis, pain sensation, immunological response, and cancer progression. TRPV …
Restoration of metal homeostasis: A potential strategy against neurodegenerative diseases
YY Zhang, XS Li, KD Ren, J Peng, XJ Luo - Ageing Research Reviews, 2023 - Elsevier
Metal homeostasis is critical to normal neurophysiological activity. Metal ions are involved in
the development, metabolism, redox and neurotransmitter transmission of the central …
the development, metabolism, redox and neurotransmitter transmission of the central …
[HTML][HTML] Effect of source and amount of vitamin D on serum concentrations and retention of calcium, magnesium, and phosphorus in dairy cows
The objectives of the experiment were to determine the effects of supplementing 2 amounts
of 25-hydroxyvitamin D 3 (calcidiol; CAL) compared with equal amounts of vitamin D 3 …
of 25-hydroxyvitamin D 3 (calcidiol; CAL) compared with equal amounts of vitamin D 3 …
Furosemide rescues hypercalciuria in familial hypomagnesaemia with hypercalciuria and nephrocalcinosis model
N Kriuchkova, T Breiderhoff, D Müller… - Acta …, 2023 - Wiley Online Library
Aim Perturbed calcium homeostasis limits life expectancy in familial hypomagnesaemia with
hypercalciuria and nephrocalcinosis (FHHNC). This rare disease occurs by loss‐of‐function …
hypercalciuria and nephrocalcinosis (FHHNC). This rare disease occurs by loss‐of‐function …
Computational and functional studies of the PI (4, 5) P2 binding site of the TRPM3 ion channel reveal interactions with other regulators
Transient receptor potential melastatin 3 (TRPM3) is a heat-activated ion channel expressed
in peripheral sensory neurons and the central nervous system. TRPM3 activity depends on …
in peripheral sensory neurons and the central nervous system. TRPM3 activity depends on …