[HTML][HTML] Scale-up of micro-and milli-reactors: An overview of strategies, design principles and applications

Z Dong, Z Wen, F Zhao, S Kuhn, T Noël - Chemical Engineering Science: X, 2021 - Elsevier
Continuous-flow microreactor technology has been embraced by researchers in academia
and industry due to its excellent transport properties and the increased safety and control …

Heterogeneous catalysis in continuous flow microreactors: A review of methods and applications

A Tanimu, S Jaenicke, K Alhooshani - Chemical Engineering Journal, 2017 - Elsevier
Over the past two decades, microreactor technology has evolved to become a crucial
component in the development of process intensification. Microreactors have helped to …

Design and scaling up of microchemical systems: a review

J Zhang, K Wang, AR Teixeira… - Annual review of …, 2017 - annualreviews.org
The past two decades have witnessed a rapid development of microreactors. A substantial
number of reactions have been tested in microchemical systems, revealing the advantages …

Compartmentalized droplets for continuous flow liquid–liquid interface catalysis

M Zhang, L Wei, H Chen, Z Du, BP Binks… - Journal of the …, 2016 - ACS Publications
To address the limitations of batch organic–aqueous biphasic catalysis, we develop a
conceptually novel method termed Flow Pickering Emulsion, or FPE, to process biphasic …

Automated microfluidic platform for systematic studies of colloidal perovskite nanocrystals: towards continuous nano-manufacturing

RW Epps, KC Felton, CW Coley, M Abolhasani - Lab on a Chip, 2017 - pubs.rsc.org
Colloidal organic/inorganic metal-halide perovskite nanocrystals have recently emerged as
a potential low-cost replacement for the semiconductor materials in commercial …

From Batch to Continuous Chemical Synthesis A Toolbox Approach

P Plouffe, A Macchi, DM Roberge - Organic Process Research & …, 2014 - ACS Publications
A toolbox approach for the transfer of batch to continuous chemical synthesis is presented.
The approach considers reaction kinetics (Type A, B, C), reacting phases (single phase …

[HTML][HTML] Scalability of mass transfer in liquid–liquid flow

A Woitalka, S Kuhn, KF Jensen - Chemical Engineering Science, 2014 - Elsevier
We address liquid–liquid mass transfer between immiscible liquids using the system 1-
butanol and water, with succinic acid as the mass transfer component. Using this system we …

Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant

M Berton, JM de Souza, I Abdiaj, DT McQuade… - Journal of Flow …, 2020 - Springer
The signature benefits of continuous flow are largely a result of a reactor's micro-sized
features. However, as the technology gains industrial traction in the synthesis of active …

Numerical insights on controlled droplet formation in a microfluidic flow-focusing device

SG Sontti, A Atta - Industrial & Engineering Chemistry Research, 2019 - ACS Publications
In this article, we have developed a computational model to determine the droplet formation
regime and its transition in a square microfluidic flow-focusing device that eventually dictate …

Liquid–liquid flow regimes and mass transfer in various micro-reactors

P Plouffe, DM Roberge, A Macchi - Chemical Engineering Journal, 2016 - Elsevier
The flow regimes and mass transfer rates in five complex micro-reactors with different mixing
mechanisms were investigated using the two-phase alkaline hydrolysis of 4-nitrophenyl …