Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Dynamic protein interactions play a significant part in many cellular processes. A technique
that shows considerable promise in elucidating such interactions is Förster resonance …

Calmodulin (CaM) is a ubiquitous, highly conserved, eukaryotic protein that binds to and
regulates a number of diverse target proteins involved in different functions such as …

The adenylyl cyclases are variously regulated by G protein subunits, a number of
serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations …

Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels
comprises a prominent prototype for ion channel regulation, remarkable for its powerful …

This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases …

Voltage-gated calcium (CaV) channels are ubiquitously expressed in various cell types
throughout the body. In principle, the molecular identity, biophysical profile, and …

Neuronal L-type calcium channels contribute to dendritic excitability and activity-dependent
changes in gene expression that influence synaptic strength. Phosphorylation-mediated …

Ca2+-dependent facilitation (CDF) of voltage-gated calcium current is a powerful
mechanism for up-regulation of Ca2+ influx during repeated membrane depolarization. CDF …