Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …

Zinc plays an important role in cardiomyocytes, where it exists in bound and histochemically
reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through …

Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses
and characterized by extensive lipid peroxidation and membrane damages. The name of …

Accumulating evidence support a causal link between Zika virus (ZIKV) infection during
gestation and congenital microcephaly. However, the mechanism of ZIKV-associated …

Myocardial ischemia causes extensive damage, further exacerbated by reperfusion, a
phenomenon called myocardial ischemia/reperfusion injury (MIRI). Nowadays, the …

Iron is an essential trace element associated with both pathologic deficiency and toxic
overload. Thus, systemic and cell iron metabolism are highly controlled processes regulated …

Increasing evidence suggests that Zn2+ acts as a second messenger capable of
transducing extracellular stimuli into intracellular signaling events. The importance of Zn2+ …

This review is aimed at providing an overview of the key hallmarks of cardiomyocytes in
physiological and pathological conditions. The main feature of cardiac tissue is the force …

Sodium-glucose cotransporter 2 (SGLT2) inhibitors showed significant effects in patients
with diabetes or metabolic syndrome (MetS) with high cardiovascular risk. Although the …

The endoplasmic reticulum (ER), an essential organelle in eukaryotic cells, is widely
distributed in myocardial cells. The ER is where secreted protein synthesis, folding, post …