Diabetic cardiomyopathy (CM), occurring in the absence of hypertension, coronary artery
disease, and valvular or congenital heart disease, is now recognized as a distinct …

Cardiac remodeling is defined as molecular, cellular, and interstitial changes that manifest
clinically as alterations in the size, shape, and function of the heart. Despite the …

Pelargonidin-3-O-glucoside (Pg) is a well-known anthocyanin derivative possessing
potential biological activity. Nonetheless, the bioactivity of Pg is limited due to instability in …

Abstract Ethnopharmacological relevance Ophiopogonin D (OP-D) is a steroidal saponin
extracted from Ophiopogon japonicus (Thunb.) Ker Gawl.(Liliaceae), that has been …

The biological activity of neohesperidin (NH, a flavanone glycoside) is limited due to
instability in the physiological environment. Thus, the current study aimed to explore the …

Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus (DM),
resulting in high mortality. Myocardial fibrosis, cardiomyocyte apoptosis and inflammatory …

Cardiac lipotoxicity is an important contributor to cardiovascular complications during
obesity. Given the fundamental role of the endoplasmic reticulum (ER)-resident …

Diabetic cardiomyopathy (DC) leads to heart failure, with few effective approaches for its
intervention. Eicosapentaenoic acid (EPA) is an essential nutrient that benefits the …

Despite decades of advancements in HIV treatment, the persistence of viral reservoirs
necessitates lifelong therapy, complicating efforts to fully control the infection. Nucleoside …

Introduction: Chronic kidney disease (CKD) can lead to significant elevation of 1-
deoxysphingolipids (1-deoxySL). The increase of 1-deoxySL in turn can result in …