Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality

AR DeCasien, E Guma, S Liu, A Raznahan - Biology of Sex Differences, 2022 - Springer
The presence, magnitude, and significance of sex differences in the human brain are hotly
debated topics in the scientific community and popular media. This debate is largely fueled …

Considering sex as a biological variable in basic and clinical studies: an endocrine society scientific statement

A Bhargava, AP Arnold, DA Bangasser… - Endocrine …, 2021 - academic.oup.com
Abstract In May 2014, the National Institutes of Health (NIH) stated its intent to “require
applicants to consider sex as a biological variable (SABV) in the design and analysis of NIH …

Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans

S Liu, J Seidlitz, JD Blumenthal… - Proceedings of the …, 2020 - National Acad Sciences
Humans display reproducible sex differences in cognition and behavior, which may partly
reflect intrinsic sex differences in regional brain organization. However, the consistency …

Whole-brain comparison of rodent and human brains using spatial transcriptomics

A Beauchamp, Y Yee, BC Darwin, A Raznahan… - Elife, 2022 - elifesciences.org
The ever-increasing use of mouse models in preclinical neuroscience research calls for an
improvement in the methods used to translate findings between mouse and human brains …

Developmental mouse brain common coordinate framework

FN Kronman, JK Liwang, R Betty, DJ Vanselow… - Nature …, 2024 - nature.com
Abstract 3D brain atlases are key resources to understand the brain's spatial organization
and promote interoperability across different studies. However, unlike the adult mouse brain …

Sex differences in the development of the rodent corticolimbic system

H Premachandran, M Zhao… - Frontiers in …, 2020 - frontiersin.org
In recent years, a growing body of research has shown sex differences in the prevalence
and symptomatology of psychopathologies, such as depression, anxiety, and fear-related …

Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure

MR Bruce, ACM Couch, S Grant, J McLellan, K Ku… - Molecular …, 2023 - nature.com
Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD).
Importantly, a clinically relevant connection exists between inflammation and metabolic …

Relating sex-bias in human cortical and hippocampal microstructure to sex hormones

S Küchenhoff, Ş Bayrak, RG Zsido, A Saberi… - Nature …, 2024 - nature.com
Determining sex-bias in brain structure is of great societal interest to improve diagnostics
and treatment of brain-related disorders. So far, studies on sex-bias in brain structure …

Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: an integrated neuroimaging, behavioral, and …

E Guma, P do Couto Bordignon, GA Devenyi… - Biological …, 2021 - Elsevier
Background Exposure to maternal immune activation (MIA) in utero is a risk factor for
neurodevelopmental disorders later in life. The impact of the gestational timing of MIA …

The role of maternal immune activation in altering the neurodevelopmental trajectories of offspring: A translational review of neuroimaging studies with implications for …

E Guma, E Plitman, MM Chakravarty - Neuroscience & Biobehavioral …, 2019 - Elsevier
Exposure to maternal infection in utero increases the risk that offspring will develop
neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia …