Covering: 2013 up to the end of 2015 This review covers the isolation and structure of new
pyrrolizidines; pyrrolizidine biosynthesis; biological activity, including the occurrence of …

The main objective of this review is to provide a comprehensive survey of methods used for
stereoselective construction of carbon–nitrogen bonds during the total synthesis of nitrogen …

Classical amination methods involve the reaction of a nitrogen nucleophile with an
electrophilic carbon center; however, in recent years, umpoled strategies have gained …

Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources.
The interest of the scientific community in these compounds owes itself to their high toxicity …

A redox-neutral α-C–H oxygenation of commercially available pyrrolidin-3-ol with a
monoprotected p-quinone generated an N-aryliminium ion intermediate, which reacted in …

A domino condensation–cyclization method is developed to synthesize indolizidine
alkaloids using a P4O10/TfOH reagent system without the employment of either a catalyst or …

A solid‐supported dipeptide‐catalyzed continuous‐flow process was developed for the
direct enantioselective α‐amination of aldehydes with dibenzyl azodicarboxylate as the …

Concise total syntheses of (R)-pipecolic acid,(R)-ethyl-6-oxopipecolate,(2R, 3R)-3-
hydroxypipecolic acid and formal syntheses of β-(+)-conhydrine,(−)-lentiginosine,(−) …

The synthesis of pyrrolidine compounds with biological interest is an active research topic.
Glycine could be a versatile starting material for making pyrrolidine derivatives. This review …

Pyrrolizidine or azabicyclo [3.3. 0]-octane (Figure 1) and its derivatives are a very common
azabicycle motif within natural products (pyrrolizidine alkaloids, PAs) possessing a bridge …