Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …

Individual cancer cells can switch, reversibly, to a non-proliferative dormant state, a process
characterized by two principal stages:(i) establishment and maintenance, and (ii) the …

Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase
with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer …

Quiescent cancer cells (QCCs), also known as dormant cancer cells, resist and survive
chemo-and radiotherapy, resulting in treatment failure and later cancer recurrence when …

The substitution of the seventeenth amino acid glutamate by lysine in the homologous
structural domain of the Akt1 gene pleckstrin is a somatic cellular mutation found in breast …

Neoadjuvant chemoimmunotherapy (NACIT) has been shown to improve pathologic
complete response (pCR) rates and survival outcomes in stage II-III triple-negative breast …

Resistance to cisplatin (DDP)-based chemotherapy is an important reason for the failure of
ovarian cancer treatment. However, tumor cells resistant to chemotherapy may expose …

Cellular quiescence is a reversible, non-cycling state controlled by epigenetic,
transcriptional and niche-associated molecular factors. Quiescence is a condition where …

The proliferation-quiescence decision is a dynamic process that remains incompletely
understood. Live-cell imaging with fluorescent cell cycle sensors now allows us to visualize …

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
death in the world. In most cases, drug resistance and tumor recurrence are ultimately …