The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTKs)
consists of EGFR, ErbB2, ErbB3, and ErbB4. These receptors play key roles in cell …

In the era of precision medicine, there is a desire to harness our improved understanding of
genomic and molecular underpinnings of gliomas to develop therapies that can be tailored …

Recent updates in the classification of central nervous system (CNS) tumors have increased
the need for molecular testing. Assessment of multiple alterations in parallel, complex …

Glioblastoma (GBM) is an incurable brain tumor for which new treatment strategies are
urgently needed. Next‐generation sequencing of GBM has most often been performed …

The authors present a cohort of 661 young adult glioblastomas diagnosed using 2016 WHO
World Health Organization Classification of Tumors of the Central Nervous System, utilizing …

Abstract Purpose Multidisciplinary tumor boards (MTBs) integrate clinical, molecular, and
radiological information and facilitate coordination of neuro-oncology care. During the …

Advanced genomic techniques have now been incorporated into diagnostic practice in
neuro-oncology in the literature. However, these assays are expensive and time-consuming …

A prompt and reliable molecular diagnosis for brain tumors has become crucial in precision
medicine. While Comprehensive Genomic Profiling (CGP) has become feasible, there …

Background and purpose The subventricular zone (SVZ) is an important niche for neural
stem cells but probably also for brain tumor propagating cells, including the glioblastoma …

A female survival benefit has been described for glioblastoma patients. Recent studies
report that the effect of 0 6-methylguanine-DNA-methyltransferase gene promoter (MGMTp) …