[HTML][HTML] Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine

S Hagan, E Martin, A Enríquez-de-Salamanca - Epma Journal, 2016 - Springer
In the field of predictive, preventive and personalised medicine, researchers are keen to
identify novel and reliable ways to predict and diagnose disease, as well as to monitor …

[HTML][HTML] Review of biomarkers in ocular matrices: challenges and opportunities

M Tamhane, S Cabrera-Ghayouri, G Abelian… - Pharmaceutical …, 2019 - Springer
Biomarkers provide a powerful and dynamic approach to improve our understanding of the
mechanisms underlying ocular diseases with applications in diagnosis, disease modulation …

[HTML][HTML] Hydrogel-based biosensors

K Völlmecke, R Afroz, S Bierbach, LJ Brenker, S Frücht… - Gels, 2022 - mdpi.com
There is an increasing interest in sensing applications for a variety of analytes in aqueous
environments, as conventional methods do not work reliably under humid conditions or they …

[HTML][HTML] Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations

X Chen, LA Aqrawi, TP Utheim, B Tashbayev… - Scientific reports, 2019 - nature.com
Investigating cytokines in tear fluid and saliva may offer valuable information for
understanding the pathogenesis of primary Sjögren's syndrome (pSS). Cytokine profiles in …

Evaluation of commonly used tear sampling methods and their relevance in subsequent biochemical analysis

A Rentka, K Koroskenyi, J Harsfalvi… - Annals of clinical …, 2017 - journals.sagepub.com
The human precorneal tear film is a special body fluid, since it is a complex mixture of
proteins, lipids, small bioactive molecules, and their concentrations and relative distribution …

[HTML][HTML] The growing need for validated biomarkers and endpoints for dry eye clinical research

NS Roy, Y Wei, E Kuklinski… - … ophthalmology & visual …, 2017 - iovs.arvojournals.org
Purpose: Biomarkers with minimally invasive and reproducible objective metrics provide the
key to future paradigm shifts in understanding of the underlying causes of dry eye disease …

Oligomeric α-synuclein is increased in basal tears of Parkinson's patients

SF Hamm-Alvarez, CT Okamoto, SR Janga… - Biomarkers in …, 2019 - Taylor & Francis
Aim: Secretion of proteins into basal tears of Parkinson's disease (PD) patients may be
altered by changes in nerve function. Materials & methods: Oligomeric α-SynOligo and total …

[HTML][HTML] Inflammation-related molecules in tears of patients with chronic ocular pain and dry eye disease

M Blanco-Vazquez, A Vazquez, I Fernandez… - Experimental Eye …, 2022 - Elsevier
The purpose of this study was to analyze inflammation-and pain-related molecules in tears
of patients suffering from chronic ocular pain associated with dry eye (DE) and/or a previous …

Sjogren's syndrome from the perspective of ophthalmology

E Kuklinski, PA Asbell - Clinical Immunology, 2017 - Elsevier
Sjogren's syndrome (SS) is an autoimmune disease affecting the lacrimal glands resulting in
dry eye disease (DED). Ophthalmologists may be the first line of detection of Sjogren's …

Tear film inflammatory cytokine upregulation in contact lens discomfort

A Gad, AJ Vingrys, CY Wong, DC Jackson, LE Downie - The ocular surface, 2019 - Elsevier
Purpose To investigate the ocular inflammatory response, using clinical and immunological
techniques, in people experiencing contact lens (CL) discomfort. Methods This study …