Phoenixin: more than reproductive peptide

M Billert, A Rak, KW Nowak, M Skrzypski - International journal of …, 2020 - mdpi.com
Phoenixin (PNX) neuropeptide is a cleaved product of the Smim20 protein. Its most common
isoforms are the 14-and 20-amino acid peptides. The biological functions of PNX are …

Regulation and physiological functions of phoenixin

H Liang, Q Zhao, S Lv, X Ji - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Phoenixin is a newly discovered neuropeptide generated from small integral membrane
protein 20. Phoenixin is a ligand for the G protein-coupled receptor 173 (GPR173) and has …

Premetazoan origin of neuropeptide signaling

LA Yañez-Guerra, D Thiel… - Molecular Biology and …, 2022 - academic.oup.com
Neuropeptides are a diverse class of signaling molecules in metazoans. They occur in all
animals with a nervous system and also in neuron-less placozoans. However, their origin …

The regulation of phoenixin: A fascinating multidimensional peptide

EK McIlwraith, N Zhang… - Journal of the Endocrine …, 2022 - academic.oup.com
The phoenixin (PNX) peptide is linked to the control of reproduction, food intake, stress, and
inflammation. However, little is known about what regulates its gene and protein expression …

Current state of phoenixin—the implications of the pleiotropic peptide in stress and its potential as a therapeutic target

T Friedrich, A Stengel - Frontiers in Pharmacology, 2023 - frontiersin.org
Phoenixin is a pleiotropic peptide, whose known functions have broadened significantly
over the last decade. Initially first described as a reproductive peptide in 2013, phoenixin is …

A systematic scoping review of the multifaceted role of phoenixin in metabolism: insights from in vitro and in vivo studies

AN Muzammil, M Barathan, MD Yazid… - Frontiers in …, 2024 - frontiersin.org
Phoenixin (PNX) is an emerging neuropeptide that plays a significant role in regulating
metabolism and reproduction. This comprehensive review examines findings from human, in …

Super-conserved receptors expressed in the brain: biology and medicinal chemistry efforts

A Bayrak, J Hanson, S Laufer… - Future Medicinal …, 2022 - Taylor & Francis
The super-conserved receptors expressed in the brain (SREB) constitute a family of orphan
G protein-coupled receptors that include GPR27 (SREB1), GPR85 (SREB2) and GPR173 …

Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem

A Pałasz, P Żarczyński, K Bogus… - Pharmacological …, 2021 - Springer
Background Phoenixin, spexin and nesfatin-1 belong to a family of newly discovered
multifunctional neuropeptides that play regulatory roles in several brain structures and …

[HTML][HTML] The deductive reasoning strategy enables biomedical breakthroughs

GLC Yosten, GR Kolar, D Salvemini… - Missouri Medicine, 2021 - ncbi.nlm.nih.gov
G protein-coupled receptors (GPCRs) transmit the signals of a variety of hormones and
neurotransmitters and are targets of more than 30% of all FDA-approved drugs. We …

Pre-metazoan origin of neuropeptide signalling

YG Luis Alfonso, T Daniel, J Gáspár - BioRxiv, 2021 - biorxiv.org
Neuropeptides are a diverse class of signalling molecules in metazoans. They occur in all
animals with a nervous system and also in neuron-less placozoans. However, their origin …