Fluorescence microscopy data describe protein localization patterns at single-cell resolution
and have the potential to reveal whole-proteome functional information with remarkable …

Evolutionary annotation of genome maintenance (GM) proteins has conventionally been
established by remote relationships within protein sequence databases. However, often no …

Abstract The Dbf4-dependent kinase Cdc7 (DDK) regulates DNA replication initiation by
phosphorylation of the MCM double hexamer (MCM-DH) to promote helicase activation …

The Saccharomyces cerevisiae silencing information regulator (SIR) complex contains up to
four proteins, namely Sir1, Sir2, Sir3, and Sir4. While Sir2 encodes a NAD‐dependent …

Transcriptional silencing in Saccharomyces cerevisiae is a persistent and highly stable form
of gene repression. It involves DNA silencers and repressor proteins that bind nucleosomes …

Reactive oxygen species (ROS) regulate several aspects of cell physiology in filamentous
fungi including the antioxidant response and development. However, little is known about …

The airborne fungus Aspergillus fumigatus causes opportunistic infections in humans with
high mortality rates in immunocompromised patients. Previous work established that the …

Homologous recombination (HR), considered the highest fidelity DNA double-strand break
(DSB) repair pathway that a cell possesses, is capable of repairing multiple DSBs without …

Organisms with smaller genomes often perform multiple functions using one multi-subunit
protein complex. The S. cerevisiae Silent Information Regulator complex (SIRc) carries out …

Las sirtuinas son una familia de enzimas dependientes de nicotinamida adenina
dinucleótido (NAD+) expresadas de manera ubicua. Sus principales funciones se ven …