The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …

Circadian clocks align behavioral and biochemical processes with the day/night cycle.
Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms …

The circadian clock and feeding rhythms are both important regulators of rhythmic gene
expression in the liver. To further dissect the respective contributions of feeding and the …

Biological clocks are genetically encoded oscillators that allow organisms to anticipate
changes in the light–dark environment that are tied to the rotation of Earth. Clocks enhance …

Circadian rhythms are oscillations of physiology, behavior, and metabolism that have period
lengths near 24 hours. In several model organisms and humans, circadian clock genes have …

Circadian (~ 24 hour) clocks have a fundamental role in regulating daily physiology. The
transcription factor BMAL1 is a principal driver of a molecular clock in mammals. Bmal1 …

Brain aging is associated with diminished circadian clock output and decreased expression
of the core clock proteins, which regulate many aspects of cellular biochemistry and …

The mammalian circadian system is a complex hierarchical temporal network which is
organized around an ensemble of uniquely coupled cells comprising the principal circadian …

The MYC oncogene encodes MYC, a transcription factor that binds the genome through
sites termed E-boxes (5′-CACGTG-3′), which are identical to the binding sites of the …