The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its “incretin effect”
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …

This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …

Replenishing insulin-producing pancreatic b cell mass will benefit both type I and type II
diabetics. In adults, pancreatic b cells are generated primarily by self-duplication. We report …

Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the
intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …

Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate …

Gastric inhibitory polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are the two
primary incretin hormones secreted from the intestine on ingestion of glucose or nutrients to …

Type 1 diabetes (T1D) is an autoimmune disease characterized by insulitis and islet β-cell
loss. Thus, an effective therapy may require β-cell restoration and immune suppression …

Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

OBJECTIVE—To examine the mechanisms of action, therapeutic potential, and challenges
inherent in the use of incretin peptides and dipeptidyl peptidase-IV (DPP-IV) inhibitors for the …

Perturbation of endoplasmic reticulum (ER) homeostasis impairs insulin biosynthesis, β cell
survival, and glucose homeostasis. We show that a murine model of diabetes is associated …