Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

Abstract Background The Mediterranean mussel Mytilus galloprovincialis is an ecologically
and economically relevant edible marine bivalve, highly invasive and resilient to biotic and …

Microgravity is associated with immunological dysfunction, though the mechanisms are
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …

Animal cells harbour multiple innate effector mechanisms that inhibit virus replication. For
the pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include …

Autophagy constitutes a mechanism for the sequestration and lysosomal degradation of
various cytoplasmic structures, including damaged organelles and invading …