Antiseizure medications in Alzheimer's disease from preclinical to clinical evidence

F Bosco, L Guarnieri, V Rania, E Palma… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) and epilepsy are common neurological disorders in the elderly. A
bi-directional link between these neurological diseases has been reported, with patients …

Tirzepatide: unveiling a new dawn in dual-targeted diabetes and obesity management

SA Rabbani, M El-Tanani, II Matalka… - Expert Review of …, 2024 - Taylor & Francis
Introduction Incretin-based therapies have emerged as effective treatments for type 2
diabetes (T2D) and obesity. However, not all patients achieve optimal outcomes with …

Adverse event profiles of antiseizure medications and the impact of coadministration on drug tolerability in adults with epilepsy

LM Willems, M van der Goten, F von Podewils, S Knake… - CNS drugs, 2023 - Springer
Background Antiseizure medication (ASM) as monotherapy or in combination is the
treatment of choice for most patients with epilepsy. Therefore, knowledge about the typical …

The oscillatory basis of working memory function and dysfunction in epilepsy

ON Arski, JM Young, ML Smith… - Frontiers in Human …, 2021 - frontiersin.org
Working memory (WM) deficits are pervasive co-morbidities of epilepsy. Although the
pathophysiological mechanisms underpinning these impairments remain elusive, it is …

Neuroprotective potential of topiramate, pregabalin and lacosamide combination in a rat model of acute SE and intractable epilepsy: Perspectives from …

Z Rehman, F Alqahtani, W Ashraf, MF Rasool… - European Journal of …, 2024 - Elsevier
The lithium-pilocarpine model is commonly used to recapitulate characteristics of human
intractable focal epilepsy. In the current study, we explored the impact of topiramate (TPM) …

[HTML][HTML] Effect of oxcarbazepine on language function in patients with newly diagnosed pediatric epilepsy

MJ Han, JH Min, SJ Kim - Journal of Clinical Neurology (Seoul …, 2023 - ncbi.nlm.nih.gov
Background and Purpose This study aimed to determine the effects of oxcarbazepine (OXC)
on the language function of patients with pediatric epilepsy. Methods We assessed the …

The Effect of Zonisamide and Ethanol on Various Types of Memory in Rats

B Pietrzak, A Krupa-Burtnik, E Zwierzyńska - International Journal of …, 2023 - mdpi.com
Background: Antiepileptic drugs might be useful in the treatment of alcohol use disorder.
One of these drugs is zonisamide, which has been found to decrease alcohol intake and …

Epilepsy and Impact on Cognition

M Rakusa - Handbook of the Behavior and Psychology of Disease, 2025 - Springer
Cognitive impairment is commonly observed in people with epilepsy (PWE), with studies
indicating that they tend to score below average on cognitive assessments, and research …

Phenotypic trade-offs: deciphering the impact of neurodiversity on drug development in fragile X syndrome

TA Bui, J Shatto, T Cuppens, A Droit… - Frontiers in Psychiatry, 2021 - frontiersin.org
Fragile X syndrome (FXS) is the most common single-gene cause of intellectual disability
and autism spectrum disorder. Individuals with FXS present with a wide range of severity in …

Sleeping High and Getting Lost on the Spiky Road: What Affects Visual Memory in Older Adults With Epilepsy, and What Can We Do About It?

R Marawar - Epilepsy Currents, 2024 - journals.sagepub.com
Epilepsy and Sleep Characteristics Are Associated With Diminished 24-h Memory Retention
in Older Adults With Epilepsy Sarkis RA, Lam AD, Pavlova M, Locascio JJ, Putta S, Puri N …