Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease and other
parkinsonisms. The various clinical aspects related to bradykinesia and the …

The huge number of neurons in the human brain are connected to form functionally
specialized assemblies. The brain's amazing processing capabilities rest on local …

The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in
the brain. Revealing its structural and functional organization is critical to understanding …

What happens in our brain when we make a decision? What triggers a neuron to send out a
signal? What is the neural code? This textbook for advanced undergraduate and beginning …

An important mechanism for large-scale interactions between cortical areas involves
coupling between the phase and the amplitude of different brain rhythms. Could basal …

The extent of synchronization within and between the nuclei of the basal ganglia is unknown
in Parkinson's disease. The question is an important one because synchronization will …

Alterations of basal ganglia physiology in parkinsonism may consist of two elements, an
increase in the firing rate of neurones and a change in the pattern of synchronisation of …

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established
therapy for patients with severe Parkinson9s disease (PD), but its mechanism of action is …

Strong synchronization of neuronal activity occurs in the 8–35 Hz band in the subthalamic
nucleus (STN) of patients with Parkinson's disease (PD) and is evident as oscillatory local …

To clarify the mechanism underlying improvement of parkinsonian signs by high-frequency
electrical stimulation (HFS) of the subthalamic nucleus (STN), we investigated the effects of …