Drug hypersensitivity reactions (DHR) are based on distinct mechanisms and are clinically
heterogeneous. Taking into account that also off‐target activities of drugs may lead to …

Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …

Drug hypersensitivity reactions (DHR) are clinically and functionally heterogeneous.
Different subclassifications based on timing of symptom appearance or type of immune …

A number of therapeutic drugs with different structures and mechanisms of action have been
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …

Drug-induced hypersensitivity reactions have been explained by the hapten concept,
according to which a small chemical compound is too small to be recognized by the immune …

Background: Lamotrigine is associated with hypersensitivity reactions, which are most
commonly characterized by skin rash. An immune etiology has been postulated, though the …

Drug hypersensitivity reactions are an important clinical problem for both health care and
industry. Recent advances in genetics have identified a number of HLA alleles associated …

Maricultured organisms are chronically exposed to water containing antibiotics but the
bioaccumulative behavior of antibiotics in exposed organisms at different growth stages has …

Drug-induced liver injury includes a spectrum of pathologies, some related to the mode of
injury, some to the cell type primarily damaged. Among these, drug-induced bile duct injury …

Adverse drug reactions are frequent and potentially life-threatening occurrences. A recent
meta-analysis of these reactions in hospitalized patients estimated an incidence of 6.7% and …