Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming
ALC Ong, TS Ramasamy - Ageing research reviews, 2018 - Elsevier
Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …
The application of histone deacetylases inhibitors in glioblastoma
R Chen, M Zhang, Y Zhou, W Guo, M Yi… - Journal of Experimental …, 2020 - Springer
The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics
that ensure the somatic inheritance of differentiated state is defined as a crucial factor …
that ensure the somatic inheritance of differentiated state is defined as a crucial factor …
The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model
Objective The aim of this study is to investigate the roles of SIRT1 and NF-κB in the
pathogenesis of diabetes mellitus in rats with STZ-induced diabetes and determine the …
pathogenesis of diabetes mellitus in rats with STZ-induced diabetes and determine the …
SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
Y Yang, W Duan, Y Lin, W Yi, Z Liang, J Yan… - Free Radical Biology …, 2013 - Elsevier
Ischemia reperfusion (IR) injury (IRI) is harmful to the cardiovascular system and causes
mitochondrial oxidative stress. Silent information regulator 1 (SIRT1), a type of histone …
mitochondrial oxidative stress. Silent information regulator 1 (SIRT1), a type of histone …
Targeting SIRT1-regulated autophagic cell death as a novel therapeutic avenue for cancer prevention
Cellular localization and deacetylation activity of Sirtuin 1 (SIRT1) has a significant role in
cancer regulation. The multifactorial role of SIRT1 in autophagy regulates several cancer …
cancer regulation. The multifactorial role of SIRT1 in autophagy regulates several cancer …
A pharmacological review on SIRT 1 and SIRT 2 proteins, activators, and inhibitors: Call for further research
M Nandave, R Acharjee, K Bhaduri, J Upadhyay… - International Journal of …, 2023 - Elsevier
Abstract Sirtuins or Sir (Silent information regulator) are NAD+-dependent enzymes playing
an important part in the pathogenesis and treatment of various disorders. They have …
an important part in the pathogenesis and treatment of various disorders. They have …
Sirtuin inhibitors as anticancer agents
Sirtuins are a class of enzymes with nicotinamide adenine dinucleotide (NAD)-dependent
protein lysine deacylase function. By deacylating various substrate proteins, including …
protein lysine deacylase function. By deacylating various substrate proteins, including …
SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis
HC Chen, YM Jeng, RH Yuan, HC Hsu… - Annals of surgical …, 2012 - Springer
Background SIRT1 is a NAD+-dependent deacetylase that plays crucial roles in many
biological processes, including stress response, apoptosis, cellular metabolism, adaptation …
biological processes, including stress response, apoptosis, cellular metabolism, adaptation …
HDAC inhibitors: roles of DNA damage and repair
C Robert, FV Rassool - Advances in cancer research, 2012 - Elsevier
Histone deacetylase inhibitors (HDACis) increase gene expression through induction of
histone acetylation. However, it remains unclear whether specific gene expression changes …
histone acetylation. However, it remains unclear whether specific gene expression changes …