Joint conditions pose an important public health problem as they are a leading cause of
pain, functional limitation and physical disability. Oxidative stress is related to the …

Chronic pain and its associated comorbidities are difficult to treat, even when the most
potent analgesic compounds are used. Thus, research on new strategies to effectively …

Naringenin is a flavonoid widely consumed by humans that present anti-inflammatory
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …

Background and purpose: Heme oxygenase (HO) activity is known to down‐regulate
inflammatory events. Here, we address the role of HO and its metabolites, carbon monoxide …

Nitric oxide (NO) is an important part of the host defense mechanism; however, it displays
both pro-and anti-inflammatory properties depending on its location and concentration …

Gouty arthritis is characterized by an intense inflammatory response to monosodium urate
crystals (MSU), which induces severe pain and reduction in the life quality of patients. Trans …

Objective This study aimed at evaluating the activity of curcumin in superoxide anion-
induced pain-like behavior and leukocyte recruitment in mice. Treatment Administration of …

Background: The administration of µ-opioid receptors (MOR) and δ-opioid receptors (DOR)
as well as cannabinoid-2 receptor (CB2R) agonists attenuates neuropathic pain. We …

Chemotherapy drugs such as vincristine can produce painful peripheral neuropathy for
which is still lack of effective treatment. Recent studies have demonstrated that …

Significance: Reactive oxygen and nitrogen species (ROS and RNS, respectively) can
intimately control neuronal excitability and synaptic strength by regulating the function of …