Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
selective and progressive loss of dopaminergic neurons. Genetic and environmental risk …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine
neurotrophic factor (CDNF) are endoplasmic reticulum (ER) luminal proteins that confer …

Background Piperine is a great lead compound, as a phytopharmaceutical with reported
neuroprotective effects in neurodegenerative diseases. HJ105, a piperine derivative with …

Psoriasis is a common chronic inflammatory skin disease that is easy to relapse and difficult
to cure. Piperine is the main alkaloid extracted from black pepper, and its role in psoriasis …

With more than 40 causative genes identified so far, autosomal dominant cerebellar ataxias
exhibit a remarkable genetic heterogeneity. Yet, half the patients are lacking a molecular …

The mesencephalic astrocyte‐derived neurotrophic factor (MANF), also named as arginine‐
rich protein (ARP) or arginine‐rich mutated in early‐stage tumors (ARMET), is a novel …

Background Acute pancreatitis was a common acute abdominal disease characterized by
pancreatic acinar cell death and inflammation. Endoplasmic reticulum autophagy (ER …

Polyglutamine spinocerebellar ataxias (polyQ SCAs) represent the most prevalent subtype
of SCAs. The primary pathogenic mechanism is believed to be the gain-of-function …

Polyglutamine spinocerebellar ataxias (polyQ SCAs) include SCA1, SCA2, SCA3, SCA6,
SCA7, and SCA17 and constitute a group of adult onset neurodegenerative disorders …