Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

Oxidative stress occurs in a variety of disease settings and is strongly linked to the
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …

Understanding the molecular mechanisms that regulate grain yield is important for
improving agricultural productivity. Protein ubiquitination controls various aspects of plant …

Degradation of proteins by the ubiquitin-proteasome system (UPS) is an essential biological
process in the development of eukaryotic organisms. Dysregulation of this mechanism leads …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

A shared hallmark for many neurodegenerative disorders is the accumulation of toxic protein
species which is assumed to be the cause for these diseases. Since the ubiquitin …

E3 ubiquitin ligase (UBE3A) levels in the brain need to be tightly regulated, as loss of
functional UBE3A protein is responsible for the severe neurodevelopmental disorder …

The ubiquitin‐proteasome system (UPS) is most widely known for its role in intracellular
protein degradation; however, in the decades since its discovery, ubiquitination has been …

Abstract The Anaphase Promoting Complex/Cyclosome (APC/C) is a multi-subunit E3
ubiquitin ligase that primarily governs cell cycle progression. APC/C is composed of at least …

Eukaryotic cell membrane dynamics change in curvature during physiological and
pathological processes. In the past ten years, a novel protein family, Fes/CIP4 homology …