Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin.
Chromatin architecture can be modified by various post‐translational modifications of …

Posttranslational modifications add tremendous complexity to proteomes; however, gaps
remain in knowledge regarding the function and regulatory mechanism of newly discovered …

Cancer cells rewire metabolism to favour the generation of specialized metabolites that
support tumour growth and reshape the tumour microenvironment,. Lysine functions as a …

Histone lysine crotonylation (Kcr), a novel posttranslational modification, is widespread as
acetylation (Kac); however, its roles are largely unknown. In this study, we report that histone …

Abstract Neuropilin-1 (NRP1), a co-receptor for various cytokines, including TGF-β, has
been identified as a potential therapeutic target for fibrosis. However, its role and …

Inflammation is a defensive reaction for external stimuli to the human body and generally
accompanied by immune responses, which is associated with multiple diseases such as …

Lysine crotonylation has been discovered in histone and non-histone proteins and found to
be involved in diverse diseases and biological processes, such as neuropsychiatric disease …

Metabolites are intermediate products of cellular metabolism catalysed by various enzymes.
Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal …

Chromatin modifications shape the epigenome and are essential for gene expression
reprogramming during plant development and adaptation to the changing environment …