Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events

D Mozaffarian, JHY Wu - Journal of the American College of Cardiology, 2011 - jacc.org
We reviewed available evidence for cardiovascular effects of n-3 polyunsaturated fatty acid
(PUFA) consumption, focusing on long chain (seafood) n-3 PUFA, including their principal …

Signaling mechanisms regulating endothelial permeability

D Mehta, AB Malik - Physiological reviews, 2006 - journals.physiology.org
The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Methods of reducing the risk of a cardiovascular event in a subject on statin therapy

P Soni - US Patent 9,610,272, 2017 - Google Patents
In various embodiments, the present invention provides methods of reducing the risk of a
cardiovascular event in a subject on statin therapy and, in particular, a method of reducing …

Stable pharmaceutical composition and methods of using same

M Manku - US Patent 8,298,554, 2012 - Google Patents
US8298554B2 - Stable pharmaceutical composition and methods of using same - Google
Patents US8298554B2 - Stable pharmaceutical composition and methods of using same …

Compositions comprising EPA and obeticholic acid and methods of use thereof

JS Zakrzewski - US Patent 9,814,733, 2017 - Google Patents
US9814733B2 - Compositions comprising EPA and obeticholic acid and methods of use
thereof - Google Patents US9814733B2 - Compositions comprising EPA and obeticholic …

[HTML][HTML] Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?

A Salameh, S Dhein - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2005 - Elsevier
Intercellular communication in many organs is maintained via intercellular gap junction
channels composed of connexins, a large protein family with a number of isoforms. This gap …

Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy

I Osterloh, P Wicker, R Braeckman, P Soni… - US Patent …, 2013 - Google Patents
US8455472B2 - Compositions and methods for lowering triglycerides without raising LDL-C
levels in a subject on concomitant statin therapy - Google Patents US8455472B2 …

Methods of treating hypertriglyceridemia

M Manku, I Osterloh, P Wicker, R Braeckman… - US Patent …, 2012 - Google Patents
In various embodiments, the present invention provides methods of treating and/or
preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy …

Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same

M Manku, I Osterloh, P Wicker, R Braeckman… - US Patent …, 2021 - Google Patents
The present invention relates to, inter alia, pharmaceutical compositions comprising EPA
and one or more cardiovascular agents, and to therapeutic methods for treating various …

Inhibitory effects of eicosapentaenoic acid (EPA) on the hypoxia/reoxygenation-induced tyrosine kinase activation in cultured human umbilical vein endothelial cells

YW Zhang, XS Yao, S Murota, I Morita - Prostaglandins, leukotrienes and …, 2002 - Elsevier
We have previously reported that the n-3 polyunsaturated fatty acid eicosapentaenoic acid
(EPA) inhibited the abnormal gap junctional intercellular communication (GJIC) induced by …