Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
[HTML][HTML] The neurobiology of social stress resulting from Racism: Implications for pain disparities among racialized minorities
Extant literature posits that humans experience two types of threat: physical threat and social
threat. While describing pain as “physical” or “social” can be helpful for understanding pain …
threat. While describing pain as “physical” or “social” can be helpful for understanding pain …
A validated predictive algorithm of post-traumatic stress course following emergency department admission after a traumatic stressor
Annually, approximately 30 million patients are discharged from the emergency department
(ED) after a traumatic event. These patients are at substantial psychiatric risk, with …
(ED) after a traumatic event. These patients are at substantial psychiatric risk, with …
Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure
Considerable racial/ethnic disparities persist in exposure to life stressors and
socioeconomic resources that can directly affect threat neurocircuitry, particularly the …
socioeconomic resources that can directly affect threat neurocircuitry, particularly the …
Persistent dissociation and its neural correlates in predicting outcomes after trauma exposure
LAM Lebois, NG Harnett… - American journal of …, 2022 - Am Psychiatric Assoc
Objective: Dissociation, a disruption or discontinuity in psychological functioning, is often
linked with worse psychiatric symptoms; however, the prognostic value of dissociation after …
linked with worse psychiatric symptoms; however, the prognostic value of dissociation after …
Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness
WH Roughan, AI Campos, LM García-Marín… - Frontiers in …, 2021 - frontiersin.org
The bidirectional relationship between depression and chronic pain is well-recognized, but
their clinical management remains challenging. Here we characterize the shared risk factors …
their clinical management remains challenging. Here we characterize the shared risk factors …
Brain-based biotypes of psychiatric vulnerability in the acute aftermath of trauma
Objective: Major negative life events, such as trauma exposure, can play a key role in
igniting or exacerbating psychopathology. However, few disorders are diagnosed with …
igniting or exacerbating psychopathology. However, few disorders are diagnosed with …
Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure
Patients exposed to trauma often experience high rates of adverse post-traumatic
neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are …
neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are …
Translating across circuits and genetics toward progress in fear-and anxiety-related disorders
KJ Ressler - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Anxiety and fear-related disorders are common and disabling, and they significantly
increase risk for suicide and other causes of morbidity and mortality. However, there is …
increase risk for suicide and other causes of morbidity and mortality. However, there is …
Development and validation of a model to predict posttraumatic stress disorder and major depression after a motor vehicle collision
Importance A substantial proportion of the 40 million people in the US who present to
emergency departments (EDs) each year after traumatic events develop posttraumatic stress …
emergency departments (EDs) each year after traumatic events develop posttraumatic stress …