Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …

Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …

Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …

Doxorubicin (DOX) is an effective antineoplastic agent of the anthracycline group. However,
as with most anticancer drugs, they cause some toxic effects, including major cardiotoxicity …

Doxorubicin (DOX) is one of the most effective chemotherapeutic drugs; however, its
incidence of cardiotoxicity compromises its therapeutic index. Chrysin, a natural flavone …

Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)–treated cancer
patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in …

Doxorubicin (DXR) is a highly effective drug for chemotherapy. However, cardiotoxicity
reduces its clinical utility in humans. The present study aimed to assess the ameliorative …

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) and the active
metabolite is rhein. It is a non-steroidal anti-inflammatory drug with unique pharmacological …

Doxorubicin (Dox) is an operational and largely used anticancer drug, used to treat an array
of malignancies. Nonetheless, its beneficial use is constrained due to its renal and …

Doxorubicin (DXR) is one of the most important chemotherapeutic agent. However,
nephrotoxicity reduces its clinical utility in humans. The aim of the study was to investigate …