Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

The sympathetic nervous system prepares the body for 'fight or flight'responses and
maintains homeostasis during daily activities such as exercise, eating a meal or regulation …

More than twelve morphologically and physiologically distinct subtypes of primary
somatosensory neuron report salient features of our internal and external environments,,–. It …

The bone marrow contains peripheral nerves that promote haematopoietic regeneration
after irradiation or chemotherapy (myeloablation), but little is known about how this is …

Cell communication within tissues is mediated by multiple paracrine signals including
growth factors, which control cell survival and proliferation. Cells and the growth factors they …

The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by
NTRK genes and have a role in the development and normal functioning of the nervous …

Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …

Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …