The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

The primary product of the renin gene is preprorenin. A signal peptide sorts renin to the
secretory pathway in juxtaglomerular cells where it is released into the circulation to initiate …

Congenital anomalies of the kidneys or lower urinary tract (CAKUT) are the most common
causes of renal failure in children and account for 25% of end-stage renal disease in adults …

Our understanding of urinary concentrating and diluting mechanisms at the end of the 20th
century was based largely on data from renal micropuncture studies, isolated perfused …

Renin cells are essential for survival perfected throughout evolution to ensure normal
development and defend the organism against a variety of homeostatic threats. During …

Juxtaglomerular cells are highly specialized myoepithelioid granulated cells located in the
glomerular afferent arterioles. These cells synthesize and release renin, which distinguishes …

Adverse events during fetal life such as insufficient protein intake or elevated transfer of
glucocorticoid to the fetus may impact cardiovascular and metabolic health later in adult life …

The kidney is a highly vascularized organ that normally receives a fifth of the cardiac output.
The unique spatial arrangement of the kidney vasculature with each nephron is crucial for …

Inhibitors of the renin-angiotensin system (RAS) are widely used to treat hypertension. Using
mice harboring fluorescent cell lineage tracers, single-cell RNA-Seq, and long-term …

Endogenous creatinine clearance (Ccr) is widely accepted as an estimate of glomerular
filtration rate (GFR), the best overall biomarker of kidney function. However, current common …