Highlights•AR is a clinically fully validated target for treatment of human prostate
cancer.•PROTAC AR degraders overcome common resistance mechanisms developed …

Seizures are a frequent pathophysiological feature of malignant glioma. Recent studies
implicate peritumoral synaptic dysregulation as a driver of brain hyperactivity and tumor …

High-grade gliomas defined by histone 3 K27M driver mutations exhibit global loss of
H3K27 trimethylation and reciprocal gain of H3K27 acetylation, respectively shaping …

Dynamic control of the actin and microtubule cytoskeletons underlie nearly every critical
process during neural development, and requires multiple dimensions of regulation …

PspA is the main effector of the phage shock protein (Psp) system and preserves the
bacterial inner membrane integrity and function. Here, we present the 3.6 Å resolution …

Cervical cancer (CeCa) is becoming an intractable public health issue worldwide. Emerging
evidence uncovers that the tumor progression and prognosis of patients with CeCa are …

Dysregulation of the ubiquitin–proteasomal system (UPS) enables pathogenic accumulation
of disease-driving proteins in neurons across a host of neurological disorders. However …

Almost 25 years have passed since a mutation of a formin gene, DIAPH1, was identified as
being responsible for a human inherited disorder: a form of sensorineural hearing loss …

Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC)
tumorigenesis involves a combination of multiple genetic alteration processes. Constructing …

Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which
can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in …