Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major
cause of morbidity and mortality worldwide, but particularly in tropical, developing countries …

The malaria parasite has an extraordinary ability to evade the immune system due to which
the development of a malaria vaccine is a challenging task. Extensive research on malarial …

Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target
proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional …

Mitochondrial proteins of Plasmodium falciparum (MPPF) are an important target for anti-
malarial drugs, but their identification through manual experimentation is costly, and in turn …

One of the first events that follows invasion of leukocytes by Theileria sporozoites is the
destruction of the surrounding host cell membrane and the rapid association of the …

Malaria is caused when Plasmodium sporozoites are injected along with saliva by an
anopheline mosquito into the dermis of a vertebrate host. Arthropod saliva has pleiotropic …

Background: malaria caused by Plasmodium parasites remains a public health threat. The
circumsporozoite proteins (CSPs) of Plasmodium sporozoite play a key role in Plasmodium …

Plasmodium vivax, one species of parasite causing human malaria, forms a dormant liver
stage, termed the hypnozoite, which activate weeks, months or years after the primary …

Liver fibrosis is a progressive physiological change that occurs after liver injury and
seriously endangers human health. The lack of reliable and physiologically relevant …

Background Plasmodium falciparum malaria is recognized as a major global public health
problem. The malaria vaccine was important because the case fatality rate of falciparum …