Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Transmission of external stimuli to intracellular effector proteins via signalling …

Cancer cachexia is a complex multi‐organ catabolic syndrome that reduces mobility,
increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of …

The condition of muscle fiber atrophy and weakness that occurs in respiratory muscles along
with systemic skeletal muscle with age is known as respiratory sarcopenia. The Japanese …

Patients with metastatic cancer experience a severe loss of skeletal muscle mass and
function known as cachexia. Cachexia is associated with poor prognosis and accelerated …

ABSTRACT The Forkhead box O (FoxO) transcription factors are activated, and necessary
for the muscle atrophy, in several pathophysiological conditions, including muscle disuse …

Background Evidence from cachectic cancer patients and animal models of cancer cachexia
supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer …

Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel
in multiple pathological conditions. However, the causative role of skeletal muscle …

New Findings What is the central question of this study? Interleukin‐6 has been associated
with muscle mass and metabolism in both physiological and pathological conditions. A …

Decline in skeletal muscle cell size (myofiber atrophy) is a key feature of cancer-induced
wasting (cachexia). In particular, atrophy of the diaphragm, the major muscle responsible for …

Low skeletal muscle mass is highly prevalent in older cancer patients and affects 5% to 89%
depending on the type and stage of cancer. Low skeletal muscle mass is associated with …