Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

Manganese is an essential trace metal. The dysregulation of manganese seen in a broad
spectrum of neurological disorders reflects its importance in brain development and key …

Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly
evolving. We seek to provide a summary of recent findings in the field, with an emphasis to …

Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

The essential metal manganese becomes neurotoxic at elevated levels. Yet, the
mechanisms by which brain manganese homeostasis is regulated are unclear. Loss-of …

Manganese (Mn) is an essential trace element that is naturally found in the environment and
is necessary as a cofactor for many enzymes and is important in several physiological …

Functional synapses in the central nervous system depend on a chemical signal exchange
process that involves neurotransmitter delivery between neurons and receptor cells in the …

Background Exposure to occupational manganese (Mn) is associated with neurotoxic brain
injury, manifesting primarily as parkinsonism. The association between environmental Mn …

Heavy metal pollution has become a global health challenge. Exposure to heavy metals
represents a major health risk. Manganese (Mn) is an essential trace element but also an …

Parkinson's disease (PD), dementia with Lewy body (DLB), progressive supranuclear palsy
(PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA) belong to a …