Members of the virus family Narnaviridae contain the simplest genomes of any RNA virus,
ranging from 2.3 to 3.6 kb and encoding only a single polypeptide that has an RNA …

It has become evident that many human disorders are characterised by mitochondrial
dysfunction either at a primary level, due to mutations in genes whose encoded products are …

To introduce DNA into mitochondria efficiently, we fused adenoassociated virus capsid VP2
with a mitochondrial targeting sequence to carry the mitochondrial gene encoding the …

Leber hereditary optic neuropathy is due to mitochondrial DNA mutations; in∼ 70% of all
cases, a point mutation in the mitochondrial NADH dehydrogenase subunit 4, ND4, gene …

The p. N478D missense mutation in human mitochondrial poly (A) polymerase (mtPAP) has
previously been implicated in a form of spastic ataxia with optic atrophy. In this study, we …

The recent revival of old theories and setting them on modern scientific rails to a large extent
are also relevant to mitochondrial science. Given the widespread belief that mitochondria …

Mitochondrial protein synthesis is essential for all mammals, being responsible for providing
key components of the oxidative phosphorylation complexes. Although only thirteen different …

The mechanisms of mitochondrial DNA replication have been hotly debated for a decade.
The strand‐displacement model states that lagging‐strand DNA synthesis is initiated from …

Considerable evidence supports mutations in mitochondrial genes as the cause of
maternally inherited diseases affecting tissues that rely primarily on oxidative energy …

Chlamydomonas reinhardtii is a photosynthetic eukaryote showing great industrial potential.
The synthesis and in vivo function of the artificial C. reinhardtii genome not only promotes …