Prostate cancer is the most commonly diagnosed cancer affecting men in the United States.
The prostate is a hormone-dependent gland in which androgen hormones testosterone and …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Background Germline mutations in BRCA1/2 and ATM have been associated with prostate
cancer (PCa) risk. Objective To directly assess whether germline mutations in these three …

Purpose To analyze the baseline clinicopathologic characteristics of prostate tumors with
germline BRCA1 and BRCA2 (BRCA1/2) mutations and the prognostic value of those …

Background The inhibition of poly (adenosine diphosphate [ADP]–ribose) polymerase
(PARP) is a potential synthetic lethal therapeutic strategy for the treatment of cancers with …

Background Genetic testing for risk of hereditary cancer can help patients to make important
decisions about prevention or early detection. US and UK studies show that people from …

Background Mutations in DNA repair genes are associated with aggressive prostate cancer
(PCa). Objective To assess whether germline mutations are associated with grade …

Background: A family history of prostate cancer (PrCa) is a strong risk factor for the disease,
indicating that inherited factors are important in this disease. We previously estimated that …

The discovery of the first gene associated with hereditary breast cancer, BRCA1, was
anticipated to greatly increase our understanding of both hereditary and sporadic forms of …

This review deals with germ-line genes that increase susceptibility to five major types of
cancer: breast, lung, pancreatic, prostate, and colorectal cancer. Often familial, often …