Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan
R Castro-Portuguez, GL Sutphin - Experimental gerontology, 2020 - Elsevier
Aging is characterized by a progressive decline in the normal physiological functions of an
organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an …
organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an …
Mitophagy, mitochondrial dynamics, and homeostasis in cardiovascular aging
Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …
diseases including cardiovascular and metabolic diseases. Ample evidence has established …
Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics
JC Campos, LH Marchesi Bozi… - Proceedings of the …, 2023 - National Acad Sciences
Exercise is a nonpharmacological intervention that improves health during aging and a
valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently …
valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently …
Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
Mitochondria undergo dynamic fusion/fission, biogenesis and mitophagy in response to
stimuli or stresses. Disruption of mitochondrial homeostasis could lead to cell senescence …
stimuli or stresses. Disruption of mitochondrial homeostasis could lead to cell senescence …
Causal roles of mitochondrial dynamics in longevity and healthy aging
Mitochondria are organized in the cell in the form of a dynamic, interconnected network.
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …
Role of mitochondria in retinal pigment epithelial aging and degeneration
Retinal pigment epithelial (RPE) cells form a monolayer between the neuroretina and
choroid. It has multiple important functions, including acting as outer blood-retina barrier …
choroid. It has multiple important functions, including acting as outer blood-retina barrier …
Dietary supplements and natural products: an update on their clinical effectiveness and molecular mechanisms of action during accelerated biological aging
Accelerated biological aging, which involves the gradual decline of organ or tissue functions
and the distortion of physiological processes, underlies several human diseases. Away from …
and the distortion of physiological processes, underlies several human diseases. Away from …
C. elegans as a model to study mitochondrial biology and disease
T Onraet, S Zuryn - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Mitochondria perform a myriad of essential functions that ensure organismal homeostasis,
including maintaining bioenergetic capacity, sensing and signalling the presence of …
including maintaining bioenergetic capacity, sensing and signalling the presence of …
Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans
Mitochondrial functions across different tissues are regulated in a coordinated fashion to
optimize the fitness of an organism. Mitochondrial unfolded protein response (UPR mt) can …
optimize the fitness of an organism. Mitochondrial unfolded protein response (UPR mt) can …
Overexpression of mitochondrial fission or mitochondrial fusion genes enhances resilience and extends longevity
The dynamicity of the mitochondrial network is crucial for meeting the ever‐changing
metabolic and energy needs of the cell. Mitochondrial fission promotes the degradation and …
metabolic and energy needs of the cell. Mitochondrial fission promotes the degradation and …