Both skin and oral mucosa are characterized by the presence of keratinized epithelium in
direct apposition to an underlying collagen-dense connective tissue. Despite significant …

Periostin, identified as a matricellular protein and an ECM protein, plays a central role in non-
neoplastic diseases. Periostin and its variants have been considered to be normally …

A substantial proportion of cancer patients do not benefit from platinum-based
chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental …

Background Elevated levels of periostin (Postn) in the cartilage and bone are associated
with osteoarthritis (OA). However, it remains unknown whether Postn loss-of-function can …

Intervertebral disc (IVD) degeneration (IVDD) is closely linked to degenerative spinal
disease, resulting in disability, poor quality of life, and financial burden. Apoptosis of nucleus …

The firm integration of anterior cruciate ligament (ACL) grafts into bones remains the most
demanding challenge in ACL reconstruction, since graft loosening means graft failure. For a …

Periostin, an extracellular matrix protein, is widely expressed in a variety of tissues and cells.
It has many biological functions and is related to many diseases: for example, it promotes …

Human periostin is a 78–91 kDa matricellular protein implicated in extracellular matrix
remodeling, tumor development, metastasis, and inflammatory diseases like atopic …

Matricellular proteins (MCPs) are defined as extracellular matrix (ECM) associated proteins
that are important regulators and integrators of microenvironmental signals, contributing to …

Objective Recent evidence delineates an emerging role of periostin in osteoarthritis (OA),
since its expression after knee injury is detrimental to the articular cartilage. We undertook …