The worst things in life are free: the role of free heme in sickle cell disease

OT Gbotosho, MG Kapetanaki, GJ Kato - Frontiers in immunology, 2021 - frontiersin.org
Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …

Sickle cell disease: role of oxidative stress and antioxidant therapy

R Vona, NM Sposi, L Mattia, L Gambardella, E Straface… - Antioxidants, 2021 - mdpi.com
Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb),
which affects approximately a million people worldwide. It is characterized by a single …

Oxidative stress in association with metabolic health and obesity in young adults

GK Jakubiak, K Osadnik, M Lejawa… - Oxidative Medicine …, 2021 - Wiley Online Library
Introduction. Obesity is one of the most important public health problems in the world.
Among obese people, there are those who, apart from excessive body weight, do not exhibit …

[HTML][HTML] Understanding apoptosis in sickle cell anemia patients: Mechanisms and implications

EI Obeagu, NI Ubosi, GU Obeagu, SI Egba, MH Bluth - Medicine, 2024 - journals.lww.com
Sickle cell anemia (SCA) is a hereditary blood disorder characterized by the presence of
abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells. While much …

Sickle cell disease update: new treatments and challenging nutritional interventions

V Bell, T Varzakas, T Psaltopoulou, T Fernandes - Nutrients, 2024 - mdpi.com
Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a
congenital blood disorder characterized by considerable phenotypic diversity. It comprises a …

Review on oxidative stress relation on COVID-19: Biomolecular and bioanalytical approach

M Ebrahimi, P Norouzi, H Aazami… - International journal of …, 2021 - Elsevier
COVID-19 disease has put life of people in stress worldwide from many aspects. Since the
virus has mutated in absolutely short period of time the challenge to find a suitable vaccine …

Keap1-Nrf2 heterodimer: a therapeutic target to ameliorate sickle cell disease

W Chauhan, R Zennadi - Antioxidants, 2023 - mdpi.com
Sickle cell disease (SCD) is a monogenic inheritable disease characterized by severe
anemia, increased hemolysis, and recurrent, painful vaso-occlusive crises due to the …

From stress to sick (le) and back again–oxidative/antioxidant mechanisms, genetic modulation, and cerebrovascular disease in children with sickle cell anemia

M Silva, P Faustino - Antioxidants, 2023 - mdpi.com
Sickle cell anemia (SCA) is a genetic disease caused by the homozygosity of the HBB: c.
20A> T mutation, which results in the production of hemoglobin S (HbS). In hypoxic …

Rheological abnormalities in human erythrocytes subjected to oxidative inflammation

T Maruyama, M Hieda, S Mawatari, T Fujino - Frontiers in Physiology, 2022 - frontiersin.org
Erythrocytes are oxygen carriers and exposed to redox cycle in oxygenation and
deoxygenation of hemoglobin. This indicates that circulating erythrocytes are vulnerable to …

[HTML][HTML] Hypoglycemic Ability of Sericin-Derived Oligopeptides (SDOs) from Bombyx mori Yellow Silk Cocoons and Their Physiological Effects on Streptozotocin (STZ …

C Tocharus, M Sutheerawattananonda - Foods, 2024 - mdpi.com
Patients with diabetes require daily medication to maintain blood sugar levels. Nevertheless,
the long-term use of antidiabetics can lose efficacy and cause degeneration in some …