RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …

Simple Summary Long non-coding RNAs (LncRNAs) are non-protein coding molecules
longer than 200 nucleotides. They play essential roles in normal cell function and …

Embryonic stem cells (ESCs) can undergo lineage-specific differentiation, giving rise to
different cell types that constitute an organism. Although roles of transcription factors and …

In spite of its high mortality rate and difficulty in finding a cure, scientific advancements have
contributed to a reduction in cancer-related fatalities. Aberrant gene expression during …

Glioblastoma multiforme (GBM) is one of the most common primary malignant brain tumors
in adults. Due to the poor prognosis of patients, the median survival time of GBM is often less …

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and multiple endocrine
neoplasia-β (MENβ) are two long noncoding RNAs upregulated in multiple cancers, marking …

In the field of precision and personalized medicine, the next generation sequencing method
has begun to take an active place as genome-wide screening applications in the diagnosis …

The escalating global incidence of cancer, which results in millions of fatalities annually,
underscores the pressing need for effective pharmacological interventions across diverse …

The development of Chemical scaffolds that target highly conserved MALAT1 RNA received
attention due to its significance in splicing, nuclear organization, and gene expression in …

Small-molecule RNA binders have emerged as an important pharmacological modality. A
profound understanding of the ligand selectivity, binding mode, and influential factors …