Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions

C Cavaleiro, GJM Afonso, PJ Oliveira… - Frontiers in Molecular …, 2023 - frontiersin.org
Stem cells have potential applications in the field of neurological diseases, as they allow for
the development of new biological models. These models can improve our understanding of …

EYE-503: A Novel Retinoic Acid Drug for Treating Retinal Neurodegeneration

S Liu, Y Ji, H Li, L Ren, J Zhu, T Yang, X Li, J Yao… - Pharmaceuticals, 2023 - mdpi.com
Retinal neurodegeneration is a major cause of vision loss. Retinoic acid signaling is critical
for the maintenance of retinal function, and its dysfunction can cause retinal …

Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2

CN Como, R O'Rourke, C Winkler, D Mitchell, LN Tran… - bioRxiv, 2024 - biorxiv.org
The meninges act as a regulator of brain development by secreting ligands that act on
neural cells to regulate neurogenesis and neuronal migration. Meningeal-derived retinoic …

Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis

FE Mancini, PEA Humphreys, S Woods, N Bates… - Scientific Reports, 2024 - nature.com
Osteoarthritis is the most common degenerative joint condition, leading to articular cartilage
(AC) degradation, chronic pain and immobility. The lack of appropriate therapies that …

Integration of bulk RNA sequencing and single-cell analysis reveals a global landscape of DNA damage response in the immune environment of Alzheimer's disease

Y Lai, H Lin, M Chen, X Lin, L Wu, Y Zhao… - Frontiers in …, 2023 - frontiersin.org
Background We developed a novel system for quantifying DNA damage response (DDR) to
help diagnose and predict the risk of Alzheimer's disease (AD). Methods We thoroughly …

Retinoic acid signaling is critical for generation of pancreatic progenitors from human embryonic stem cells

NP Dumasia, AP Khanna, PS Pethe - Growth Factors, 2023 - Taylor & Francis
Retinoic acid (RA) is essential for gut endoderm development and has been extensively
used for in vitro pancreatic differentiation from human pluripotent stem cells. However, the …