Targeted protein degradation (TPD) is an emerging modality for research and therapeutics.
Most TPD approaches harness cellular ubiquitin-dependent proteolytic pathways …

Highlights•PBMs promote the spatial proximity of POIs to kinases/phosphatases to induce
phosphorylation/dephosphorylation of POIs.•PBMs emerge as promising paradigms for the …

We recently developed a heterobifunctional approach [phosphorylation targeting chimeras
(PhosTACs)] to achieve the targeted protein dephosphorylation (TPDephos). Here, we …

Fragment screening is used to identify binding sites and leads in drug discovery, but it is
often unclear which binding sites are functionally important. Here, data from 37 experiments …

Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular
responses to metabolic and other stresses. During nutrient replete and stressor-free …

The complexity of the cellular proteome is massively expanded by a repertoire of chemically
distinct reversible post-translational modifications (PTMs) that control protein localisation …

TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes
and its dysregulation has been implicated in many human diseases, including fibrosis and …

Reversible protein phosphorylation directs essential cellular processes including cell
division, cell growth, cell death, inflammation, and differentiation. Because protein …

Maintaining normal cellular behavior is essential for the survival of organisms. One of the
main mechanisms to control cellular behavior is protein phosphorylation. The process of …

The coordination between kinases and phosphatases is crucial for regulating the
phosphorylation levels of essential signaling molecules. Methods enabling precise control of …