Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations

S Soltani, R Hammami, PD Cotter… - FEMS microbiology …, 2021 - academic.oup.com
In recent decades, bacteriocins have received substantial attention as antimicrobial
compounds. Although bacteriocins have been predominantly exploited as food …

Biomedical applications of nisin

JM Shin, JW Gwak, P Kamarajan… - Journal of applied …, 2016 - academic.oup.com
Nisin is a bacteriocin produced by a group of Gram‐positive bacteria that belongs to
Lactococcus and Streptococcus species. Nisin is classified as a Type A (I) lantibiotic that is …

Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides

I Greco, N Molchanova, E Holmedal, H Jenssen… - Scientific reports, 2020 - nature.com
The use of non-standard toxicity models is a hurdle in the early development of antimicrobial
peptides towards clinical applications. Herein we report an extensive in vitro and in vivo …

Bacteriocins—a viable alternative to antibiotics?

PD Cotter, RP Ross, C Hill - Nature Reviews Microbiology, 2013 - nature.com
Solutions are urgently required for the growing number of infections caused by antibiotic-
resistant bacteria. Bacteriocins, which are antimicrobial peptides produced by certain …

Applications and evolution of melittin, the quintessential membrane active peptide

S Guha, RP Ferrie, J Ghimire, CR Ventura, E Wu… - Biochemical …, 2021 - Elsevier
Melittin, the main venom component of the European Honeybee, is a cationic linear peptide-
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …

Gut microbiota as a source of novel antimicrobials

E Garcia-Gutierrez, MJ Mayer, PD Cotter, A Narbad - Gut microbes, 2019 - Taylor & Francis
ABSTRACT Bacteria, Archaea, Eukarya and viruses coexist in the human gut, and this
coexistence is functionally balanced by symbiotic or antagonistic relationships. Antagonism …

Intestinal permeation enhancers for oral peptide delivery

S Maher, RJ Mrsny, DJ Brayden - Advanced drug delivery reviews, 2016 - Elsevier
Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to
improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation …

Mechanistic landscape of membrane-permeabilizing peptides

S Guha, J Ghimire, E Wu, WC Wimley - Chemical reviews, 2019 - ACS Publications
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Bacteriocins as potential anticancer agents

S Kaur, S Kaur - Frontiers in pharmacology, 2015 - frontiersin.org
Cancer remains one of the leading causes of deaths worldwide, despite advances in its
treatment and detection. The conventional chemotherapeutic agents used for the treatment …

Antimicrobial peptides and nanotechnology, recent advances and challenges

LS Biswaro, MG da Costa Sousa… - Frontiers in …, 2018 - frontiersin.org
Antimicrobial peptides are sequences of amino acids, which present activity against
microorganisms. These peptides were discovered over 70 years ago, and are abundant in …