The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …

Significant insights into the function of genes associated with Alzheimer disease and related
dementias have occurred through studying genetically modified animals. Although none of …

Neural stem cell (NSC) transplantation represents an unexplored approach for treating
neurodegenerative disorders associated with cognitive decline such as Alzheimer disease …

Alzheimer's disease (AD), the most prevalent age-related neurodegenerative disorder, is
characterized pathologically by the accumulation of β-amyloid (Aβ) plaques and tau-laden …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …

Microglia mediate chronic neuroinflammation following central nervous system (CNS)
disease or injury, and in doing so, damage the local brain environment by impairing …

With severe injury or disease, microglia become chronically activated and damage the local
brain environment, likely contributing to cognitive decline. We previously discovered that …

In this review, we consider the evidence that a reduction in neurogenesis underlies aging-
related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD) …

Alzheimer's disease (AD) is the most prevalent age‐related neurodegenerative disorder,
affecting over 35 million people worldwide. Pathologically, AD is characterized by the …

Microtubules form important cytoskeletal structures that play a role in establishing and
maintaining neuronal polarity, regulating neuronal morphology, transporting cargo, and …