Chemical approaches to cryopreservation

KA Murray, MI Gibson - Nature Reviews Chemistry, 2022 - nature.com
Cryopreservation of cells and biologics underpins all biomedical research from routine
sample storage to emerging cell-based therapies, as well as ensuring cell banks provide …

Recent advances in macroporous hydrogels for cell behavior and tissue engineering

Y Ma, X Wang, T Su, F Lu, Q Chang, J Gao - Gels, 2022 - mdpi.com
Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion,
proliferation, migration, and differentiation because of their high-water content and …

Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review

B Knap, D Nieoczym, U Kundap… - Frontiers in Molecular …, 2023 - frontiersin.org
Traditionally, selected plant sources have been explored for medicines to treat convulsions.
This continues today, especially in countries with low-income rates and poor medical …

Size and shape control of ice crystals by amphiphilic block copolymers and their implication in the cryoprotection of mesenchymal stem cells

JK Park, M Patel, Z Piao, SJ Park… - ACS Applied Materials & …, 2021 - ACS Publications
Precise control over the size and shape of ice crystals is a key factor to consider in designing
antifreezing and cryoprotecting molecules for cryopreservation of cells. Here, we report that …

Principles and protocols for post-cryopreservation quality evaluation of stem cells in novel biomedicine

J Xie, MD Ekpo, J Xiao, H Zhao, X Bai… - Frontiers in …, 2022 - frontiersin.org
Stem cell therapy is a thriving topic of interest among researchers and clinicians due to
evidence of its effectiveness and promising therapeutic advantage in numerous disease …

Low DMSO cryopreservation of stem cells enabled by macromolecular cryoprotectants

KA Murray, RMF Tomás, MI Gibson - ACS applied bio materials, 2020 - ACS Publications
Mesenchymal stromal (stem) cells have potential in regenerative medicine and modulating
the immune system. To deliver any cell-based therapy to the patient, it must be …

Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections

KT Peng, YC Chiang, TY Huang, PC Chen… - International journal …, 2019 - Taylor & Francis
Background Periprosthetic joint infections (PJIs) have a high incidence of recurrence after
total joint replacement and are difficult to treat by debridement or antibiotic treatment …

Human Natural Killer Cells Cryopreserved without DMSO Sustain Robust Effector Responses

S Das, E Niemeyer, ZA Leung, T Fritsch… - Molecular …, 2024 - ACS Publications
Natural killer (NK) cell-based immunotherapy has benefitted from the multiple strengths that
NK cells offer in adoptive transfer settings, not the least of which is their safety and potential …

Proline pre-conditioning of Jurkat cells improves recovery after cryopreservation

A Murray, P Kilbride, MI Gibson - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Cell therapies such as allogenic CAR T-cell therapy, natural killer cell therapy and stem cell
transplants must be cryopreserved for transport and storage. This is typically achieved by …

Direct interactions between cationic liposomes and bacterial cells ameliorate the systemic treatment of invasive multidrug-resistant Staphylococcus aureus infections

R Guo, Y Liu, K Li, B Tian, W Li, S Niu… - … , Biology and Medicine, 2021 - Elsevier
Invasive infections caused by antibiotic-resistant Staphylococcus aureus have posed a great
threat to human health. To tackle this problem, a cationic liposomal Curcumin (C-LS/Cur) …