Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …

Great successes have been achieved in developing small-molecule kinase inhibitors as
anticancer therapeutic agents. However, kinase deregulation plays essential roles not only …

Neuropathic pain (NP) is a chronic condition that results from a lesion or disease of the
nervous system, greatly impacting patients' quality of life. Current pharmacotherapy options …

In recent studies, brain stimulation has shown promising potential to alleviate chronic pain.
Although studies have shown that stimulation of pain-related brain regions can induce pain …

Neuropathic pain is difficult to cure and is often accompanied by emotional and
psychological changes. Exploring the mechanisms underlying neuropathic pain will help to …

Background A series of known Food and Drug Administration (FDA) approved anticancer
drugs were collected from the literature and docked against mTOR receptor which has been …

Currently, non-alcoholic fatty liver disease (NAFLD) progressing into chronic non-alcoholic
steatohepatitis (NASH), liver cirrhosis, and eventually hepatocellular cancer has emerged as …

Bone cancer pain (BCP) is a clinical refractory mixed pain involving neuropathic and
inflammatory pain, with the underlying mechanisms remaining largely unknown. Electro …

Aims The clinical use of brain stimulation is attractive for patients who have side effects or
tolerance. However, studies on insular cortex (IC) stimulation are lacking in neuropathic …