Redox regulation of cancer metastasis: molecular signaling and therapeutic opportunities
W Yang, L Zou, C Huang, Y Lei - Drug development research, 2014 - Wiley Online Library
Abstract Preclinical Research Cancer metastasis is the major cause of cancer‐related
mortality. Accumulated evidence has shown that high‐metastasis potential cancer cells have …
mortality. Accumulated evidence has shown that high‐metastasis potential cancer cells have …
Insights into the role of tick salivary protease inhibitors during ectoparasite–host crosstalk
MA Jmel, H Aounallah, C Bensaoud, I Mekki… - International Journal of …, 2021 - mdpi.com
Protease inhibitors (PIs) are ubiquitous regulatory proteins present in all kingdoms. They
play crucial tasks in controlling biological processes directed by proteases which, if not …
play crucial tasks in controlling biological processes directed by proteases which, if not …
Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells
B Chantong, DV Kratschmar, A Lister… - Journal of …, 2014 - Springer
Background Activation of metabotropic glutamate receptor 5 (mGluR5) by (RS)-2-chloro-5-
hydroxyphenylglycine (CHPG) was shown to suppress microglia activation and decrease …
hydroxyphenylglycine (CHPG) was shown to suppress microglia activation and decrease …
Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress
J Moon, SS Koh, W Malilas, IR Cho… - European journal of …, 2014 - Elsevier
Since it has been known that shikonin derived from a medicinal plant possesses anti-cancer
activity, we wonder whether acetylshikonin (ASK), a derivate of shikonin, can be used to …
activity, we wonder whether acetylshikonin (ASK), a derivate of shikonin, can be used to …
[HTML][HTML] Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model
JG de Souza, KLP Morais, E Anglés-Cano, P Boufleur… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Renal cell carcinoma (RCC), also called kidney cancer or renal adenocarcinoma, is highly
resistant to current treatments. It has been previously reported that a Kunitz-type inhibitor …
resistant to current treatments. It has been previously reported that a Kunitz-type inhibitor …
Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell
KLP Morais, MTF Pacheco, CM Berra… - Molecular and Cellular …, 2016 - Springer
During the last two decades, new insights into proteasome function and its role in several
human diseases made it a potential therapeutic target. In this context, Amblyomin-X is a …
human diseases made it a potential therapeutic target. In this context, Amblyomin-X is a …
[HTML][HTML] poly (I: C) synergizes with proteasome inhibitors to induce apoptosis in cervical cancer cells
X Meng, X Cui, X Shao, Y Liu, Y Xing, V Smith… - Translational …, 2022 - Elsevier
Cervical cancer is one of the most common malignancies in women, with a poor survival
rate. Thus, there is a need to define effective combination strategies to improve therapy. In …
rate. Thus, there is a need to define effective combination strategies to improve therapy. In …
Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity
Amblyomin-X is a Kunitz-type FXa inhibitor identified through the transcriptome analysis of
the salivary gland from Amblyomma sculptum tick. This protein consists of two domains of …
the salivary gland from Amblyomma sculptum tick. This protein consists of two domains of …