Tularemia is a zoonosis of humans caused by infection with the facultative intracellular
bacterium Francisella tularensis. Interest in F. tularensis has increased markedly in the past …

The immune response to intracellular bacterium, Francisella tularensis, which causes
tularemia and is proposed to be a potential bioterrorism pathogen, has been studied in mice …

The myeloid differentiation primary response gene 88 (Myd88) is critical for protection
against pathogens. However, we demonstrate here that MyD88 expression in B cells inhibits …

Though much is known about the function of T lymphocytes in the adaptive immune
response against Mycobacterium tuberculosis, comparably little is understood regarding the …

Francisella tularensis is a gram-negative, facultative intracellular pathogen that causes the
highly infectious zoonotic disease tularemia. We have discovered a ca. 30-kb pathogenicity …

Francisella tularensis causes the human disease tularemia. F. tularensis is able to survive
and replicate within macrophages, a trait that has been correlated with its high virulence, but …

Francisella tularensis is an obligate, intracellular bacterium that causes acute, lethal disease
following inhalation. As an intracellular pathogen F. tularensis must invade cells, replicate …

Although IFN-γ is necessary for survival of Mycobacterium tuberculosis infection in people
and animal models, it may not be sufficient to clear the infection, and IFN-γ is not a reliable …

Francisella tularensis is an obligate intracellular bacterium that induces severe, acute, often
fatal disease when acquired by the respiratory route. Despite the seriousness of this …

Studies of immune responses to Francisella have been conducted for well over 50 years.
Here, the basic parameters of innate and adaptive immune responses to Francisella are …