Platelets perform a central role in haemostasis and thrombosis. They adhere to
subendothelial collagens exposed at sites of blood vessel injury via the glycoprotein (GP) Ib …

Snake venom contains mixture of bioactive proteins and polypeptides. Most of these
proteins and polypeptides exist as monomers, but some of them form complexes in the …

Abstract Convulxin (CVX), a C-type lectin-like protein isolated from the venom of the snake
species, Crotalus durissus terrificus, stimulates platelet aggregation by acting as a collagen …

Injuries to the vessel wall and subsequent exposure of collagen from the subendothelial
matrix result in thrombus formation. In physiological conditions, the platelet plug limits blood …

We have previously shown that uncharacterized glycoprotein VI (GPVI), which is
constitutively associated and coexpressed with Fc receptor γ chain (FcRγ) in human …

Glycoprotein VI (GPVI) is a platelet-specific glycoprotein that has been indicated to react with
collagen and activate platelets. Its structure was recently identified by cDNA cloning …

The pathophysiology of microthrombocytopenia in the Wiskott-Aldrich syndrome (WAS) and
its milder form, X-linked thrombocytopenia (XLT), is unclear. Although quantitative defects …

C-type lectin-like proteins (CLPs) have a variety of biological activities, including
anticoagulant-and platelet-modulating activities but have no lectin activity. CLPs are made …

Platelet aggregation and acute inflammation are key processes in vertebrate defense to a
skin injury. Recent studies uncovered the mediation of 2 serine proteases, cathepsin G and …

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is a 130-kd transmembrane
glycoprotein and a member of the growing family of receptors with immunoreceptor tyrosine …