Pericytes and neurovascular function in the healthy and diseased brain

LS Brown, CG Foster, JM Courtney, NE King… - Frontiers in cellular …, 2019 - frontiersin.org
Pericytes are multi-functional cells embedded within the walls of capillaries throughout the
body, including the brain. Pericytes were first identified in the 1870s, but little attention was …

Deformation of red blood cells, air bubbles, and droplets in microfluidic devices: Flow visualizations and measurements

D Bento, RO Rodrigues, V Faustino, D Pinho… - Micromachines, 2018 - mdpi.com
Techniques, such as micropipette aspiration and optical tweezers, are widely used to
measure cell mechanical properties, but are generally labor-intensive and time-consuming …

Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique

R Agrawal, T Smart, J Nobre-Cardoso, C Richards… - Scientific reports, 2016 - nature.com
A pilot cross sectional study was conducted to investigate the role of red blood cells (RBC)
deformability in type 2 diabetes mellitus (T2DM) without and with diabetic retinopathy (DR) …

A computational study of red blood cell deformability effect on hemodynamic alteration in capillary vessel networks

S Ebrahimi, P Bagchi - Scientific reports, 2022 - nature.com
Capillary blood vessels, the smallest vessels in the body, form an intricate network with
constantly bifurcating, merging and winding vessels. Red blood cells (RBCs) must navigate …

Red blood cell deformation in microconfined flow

G Tomaiuolo, M Simeone, V Martinelli, B Rotoli… - Soft Matter, 2009 - pubs.rsc.org
In this work, we report on a systematic fluidodynamic investigation of red blood cell (RBC)
suspensions flowing in microcapillaries with diameters comparable to the cell size in vitro …

Direct numerical simulation of cellular-scale blood flow in 3D microvascular networks

P Balogh, P Bagchi - Biophysical journal, 2017 - cell.com
We present, to our knowledge, the first direct numerical simulation of 3D cellular-scale blood
flow in physiologically realistic microvascular networks. The vascular networks are designed …

Persistent red blood cells retain their ability to move in microcapillaries under high levels of oxidative stress

NA Besedina, EA Skverchinskaya, SV Shmakov… - Communications …, 2022 - nature.com
Oxidative stress is one of the key factors that leads to red blood cells (RBCs) aging, and
impairs their biomechanics and oxygen delivery. It occurs during numerous pathological …

Electrical measurement of red blood cell deformability on a microfluidic device

Y Zheng, J Nguyen, C Wang, Y Sun - Lab on a Chip, 2013 - pubs.rsc.org
This paper describes a microfluidic system and a technique for electrically measuring the
deformability of red blood cells (RBCs). RBCs are deformed when they flow through a small …

Microconfined flow behavior of red blood cells in vitro

S Guido, G Tomaiuolo - Comptes Rendus Physique, 2009 - Elsevier
The high red blood cell (RBC) deformability is essential to optimal gas exchange between
gas and tissues in microcirculation in vivo. This review is focused on the flow behavior of …

Label free measurement of retinal blood cell flux, velocity, hematocrit and capillary width in the living mouse eye

A Guevara-Torres, A Joseph… - Biomedical optics express, 2016 - opg.optica.org
Measuring blood cell dynamics within the capillaries of the living eye provides crucial
information regarding the health of the microvascular network. To date, the study of single …