Pre-twisting for improved genome modification and miRNA targeting
Two reports by Dhuri et al. and Oyaghire et al., respectively, show that, through installing
chiral centers at the backbone of the artificial nucleic acid, peptide nucleic acid (PNA) …
chiral centers at the backbone of the artificial nucleic acid, peptide nucleic acid (PNA) …
Development of bioconjugate-based delivery systems for nucleic acids
Nucleic acids are a class of drugs that can modulate gene and protein expression by various
mechanisms, namely, RNAi, mRNA degradation by RNase H cleavage, splice modulation …
mechanisms, namely, RNAi, mRNA degradation by RNase H cleavage, splice modulation …
Exploring the therapeutic potential of sγPNA-141: Pharmacodynamics and mechanistic insights during ischemic stroke recovery
MicroRNA-141-3p plays a detrimental role in the pathology of ischemic stroke, presenting a
new target for stroke treatment. This study introduces and validates a novel class of peptide …
new target for stroke treatment. This study introduces and validates a novel class of peptide …
Selective Recruitment of Antibodies to Cancer Cells and Immune Cell‐mediated Killing via In Situ Click Chemistry
E Ankrom, B Dalesandro, MM Pires… - ChemMedChem, 2024 - Wiley Online Library
Many current cancer immunotherapies function by redirecting immune system components
to recognize cancer biomarkers and initiate a cytotoxic attack. The lack of a universal tumor …
to recognize cancer biomarkers and initiate a cytotoxic attack. The lack of a universal tumor …